If you are talking about true sewer gas smell, then you have some kind of leak up through the S-shaped 'trap' - usually b/c the water has evaporated or been pulled in, and there is no longer a water-seal working there. If running a little water down the main drain makes it stop/go away than this is the issue, and probably means your roof vent system is somehow blocked, or otherwise s/t is doing weird things to pull out the trap-water. If it is a drain you seldom use, like a guest bath, it can just dry out. If it is just the smell of the junk built up, then try the hot water first, perhaps with some TSP or cleaning soap in it (I haven't used drano in decades, and would discourage it - those plastic hair snags or a snake are all I've needed).
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