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I've done the drive from SD to Seattle twice in the last year. 3 days is tight if you want to do any sightseeing.
What I'd recommend: take the 5 the majority of the way. There a couple spots where you'll want to get over to the 101. Around the San Luis Obispo area cut over to the 101. Take it through the San Simeon area up through Big Sur. Past SF you can continue up the 101 to the Avenue of the Giants. After that, I'd head back to the 5 and towards Portland.
With 3 days, just these 101 detours will be cutting it close. Oregon and Washington coasts are tempting, but you just won't have the time.
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