I have two friends who did just that. They cut the weather strip out and after a month one of them noticed a weird smell coming from the door panel. It turned out water was getting in from the rain and there was mold growing inside his door panel. Yuuuuck!
I noticed wind noise was louder at speed. Seemed like wind was getting in since the seal wasn't tight anymore.
I would rather spend $30 for the moleskin above then cut the weather strip seals out of my 50k car. JMHO
