The IS350 has posted better than 5.1s but who said more power equals quicker 0-60mph times, the fact still remains that trying to get an extra 100+hp to the road surface with only two wheels doing the driving is harder and when you add the factor that only 46% of the weigh is now over these wheels (less than the IS350) it's amazing it's posting 4.8s at all. A better time to check out is 0-100 or 0-150mph and see how the IS-F is performing compared to the M3 and others, if by these speeds the thing is close then Lexus has done a good job with the engine and transmission.
Now the chassis, that's a different story and deserves another thread all on it's own.