I doubt any problems would occur. Just be cautious of how you are feeling.
In college we use to take hydrocodone and other muscle relaxers while smoking.
My friends for some reason got the bright idea to crush some up and sprinkle it on top of the weed before hitting the bong. I never saw the point and didn't think it did anything. They thought it did though.
Then again, they also snorted the pills too. Talk about stupid.