Such an opened ended ?
too hard to sum up w/o writing a book
Take lots of cash
Bring your own booze if you are driving ( dont drive like an idiot either, get there safe...there are some spots where you can "safely" hit 100mph on the 15
Have an open mind..there are LOTS of things to do and bars/clubs in all the major spots..
you just have to go there and experience it for yourself....
if you want to get into the high-end clubs like others mentioned..find some chicks also trying to get in and ask them if they woudl like to join you in getting in, then use them as a bargaining chip to the bouncers ( youll see what I mean when you get there)
women EVERYWHERE and from EVERYWHERE its awesome
vegas.com is a good resource for what/where questions....
my personal favs are
Hardrock ( off the strip tho)
g/l and come back in 1 piece