I've installed and driven several on E9x M3s. They really like the extra air, but the power output is not what it is at the lower altitudes. Don't get me wrong, it's no slouch with a ~600hp kit! The thin air does present it's own tuning issues that cannot be overcome without on site tuning. Nothing major, but slight hiccups here and there. I may be able to set up a ride if you like, once you are here. As far as does it work the car harder, not any more so that at or close to sea level. I've owned multiple supercharged vehicles, but the only M I did that to was my E36. Never had an issue with engine damage on any platform and I know I see more of them than anyone in the springs.
What kit are you looking into?