Yes, I am really looking forward to it. I have about ten playthroughs that cover a bunch of different choice variations, and am looking forward to getting through as many of them as possible.
If you like the ME-type experience in a (modern era-type) RPG, I thought Alpha Protocol was interesting, too. The only bad thing about that game was the shooter angle was rather badly done. The story was good, though, and the ability to radically change the direction of the story (far more so than in Mass Effect,) was neat.