The S54 from the E46 M3 was shared with the Z4Ms...unlike the S65. The E9x is nearing the end of its production do I'm sure BMW has ramped down S65 production. I think these fears are overblown. The key ingredient of most of the failures is FI. Although there have been some NA failures...this is the rare exception. Consider how these cars are being beaten on...I meant driven.
2015 F34 328iX GT Glacier Silver
2011 E90 M3 Monte Carlo Blue
2004 E46 M3 Imola Red